Breakthrough Israeli Study May Lead to Melanoma Cure

39
4233
(Shutterstock)

Israeli researchers believe their findings can lead to better diagnosis and prevention for the deadly skin cancer.

Israeli and European researchers say their collaborative research has unraveled the metastatic mechanism of melanoma, the most aggressive of all skin cancers.

According to a paper published August 22 in the journal Nature Cell Biology, the scientists discovered that before spreading to other organs, a melanoma tumor sends out tiny vesicles containing molecules of microRNA. These cause morphological (structural) changes in the skin’s dermis layer in preparation for receiving and transporting the cancer cells.

The researchers also found chemical substances that can stop the process and are therefore promising drug candidates.

“The threat of melanoma is not in the initial tumor that appears on the skin, but rather in its metastasis — in the tumor cells sent off to colonize in vital organs like the brain, lungs, liver and bones,” said research leader Dr. Carmit Levy of the department of human molecular genetics and biochemistry at Tel Aviv University’s Sackler School of Medicine.

“We have discovered how the cancer spreads to distant organs and found ways to stop the process before the metastatic stage.”

Diagnosis and prevention

Melanoma, the most aggressive and lethal type of skin cancer, kills one person every 52 minutes according to data from the Skin Cancer Foundation, and the number of diagnosed cases has been on the rise for the past three decades. Despite a range of therapies developed over the years, there is still no full cure for this life-threatening disease. The new study proposes novel and effective methods for diagnosis and prevention.

The researchers began by examining pathology samples taken from melanoma patients before the invasive stage.

“To our surprise we found changes in the morphology of the dermis — the inner layer of the skin — that had never before been reported,” said Levy. “Our next task was to find out what these changes were, and how they related to melanoma.”

The group was able to discover and block a central mechanism in the metastasis of melanoma.

Then they looked for substances that could intervene and block the process in its earliest stages. They found two such chemicals: one that inhibits the delivery of the vesicles from the melanoma tumor to the dermis; and another that prevents the morphological changes in the dermis even after the arrival of the vesicles.

Both chemicals were tested successfully in the lab, and may serve as promising candidates for future drugs. In addition, the changes in the dermis, as well as the vesicles themselves, can be used as powerful indicators for early diagnosis of melanoma.

How skin cancer spreads

According to Levy, scientists have known for years that melanoma forms in the outer layer of the skin, the epidermis. At this early stage, the cancer cannot send out colonizing cancer cells because it has no access to blood vessels — the highways that carry the cells to other parts of the body.

So how does the tumor make contact with the abundant blood vessels running through the dermis?

“We found that even before the cancer itself invades the dermis, it sends out tiny vesicles containing molecules of microRNA,” Levy explained. “These induce the morphological changes in the dermis in preparation for receiving and transporting the cancer cells.

“It then became clear to us that by blocking the vesicles, we might be able to stop the disease altogether.”

The TAU group worked in close collaboration with Prof. Jörg D. Hoheisel and Laureen Sander at the German Cancer Research Center in Germany, Dr. Shoshi Greenberger at the Sheba Medical Center at Tel HaShomer, Israel, and Dr. Ronen Brenner at the Wolfson Medical Center in Holon, Israel. Lab research was led by Dr. Shani Dror of Levy’s research group. Other team members were from Université Paris, Massachusetts General Hospital, the Technion-Israel Institute of Technology and the Hebrew University of Jerusalem.

“Our study is an important step on the road to a full remedy for the deadliest skin cancer,” said Levy. “We hope that our findings will help turn melanoma into a nonthreatening, easily curable disease.”

 

 

 

Source: Israel21c

39 COMMENTS

  1. Hi there, I found your blog by way of Google while looking for a related subject, your site
    came up, it appears great. I have bookmarked it in my google
    bookmarks.
    Hello there, simply turned into aware of your weblog thru
    Google, and located that it’s really informative. I’m going to be careful for brussels.
    I’ll be grateful should you continue this in future. Many people will be
    benefited out of your writing. Cheers!

  2. Thanks for every other fantastic post. The place else could anybody get that kind of information in such a perfect manner of writing?
    I’ve a presentation next week, and I am on the look for such information.

  3. Hi would you mind letting me know which hosting company you’re using?
    I’ve loaded your blog in 3 completely different web browsers and I must say this blog loads a
    lot faster then most. Can you recommend a good web
    hosting provider at a reasonable price? Many thanks, I appreciate it!

  4. I simply want to say I am new to weblog and really loved you’re website. Most likely I’m want to bookmark your site . You certainly have impressive articles. Kudos for sharing your web-site.

  5. I just want to mention I am all new to blogging and site-building and truly savored you’re page. Very likely I’m going to bookmark your blog post . You certainly have amazing articles and reviews. Kudos for revealing your blog site.

  6. Hi! Someone in my Facebook group shared this site with us so I came to check it out. I’m definitely loving the information. I’m bookmarking and will be tweeting this to my followers! Superb blog and fantastic design and style.

  7. you’re in point of fact a excellent webmaster. The web site loading speed is amazing. It kind of feels that you’re doing any unique trick. In addition, The contents are masterpiece. you’ve performed a excellent task on this subject!

  8. I¡¦m now not certain where you’re getting your info, however good topic. I needs to spend some time finding out more or working out more. Thanks for magnificent information I used to be in search of this info for my mission.

  9. I’ve been surfing on-line more than 3 hours nowadays, but I never found any attention-grabbing article like yours. It’s lovely price enough for me. In my opinion, if all site owners and bloggers made good content as you probably did, the web will probably be much more useful than ever before.

  10. Some really superb posts on this internet site, appreciate it for contribution. “When he has ceased to hear the many, he may discern the One – the inner sound which kills the outer.” by H Hahn Blavatsky.

  11. Do you have a spam problem on this site; I also am a blogger, and I was wanting to know your situation; many of us have developed some nice methods and we are looking to exchange strategies with others, please shoot me an email if interested.

  12. Undeniably believe that which you stated. Your favorite justification seemed to be on the net the easiest thing to be aware of. I say to you, I definitely get irked while people think about worries that they just don’t know about. You managed to hit the nail upon the top and defined out the whole thing without having side effect , people could take a signal. Will probably be back to get more. Thanks

  13. Hello there! I could have sworn I’ve visited your blog before but after going
    through a few of the articles I realized it’s new to me.
    Regardless, I’m certainly pleased I found it and I’ll be book-marking it and checking
    back frequently!

  14. I cling on to listening to the news update speak about getting free online grant applications so I have been looking around for the most excellent site to get one. Could you advise me please, where could i find some?

  15. Howdy very nice website!! Guy .. Excellent .. Amazing .. I will bookmark your web site and take the feeds additionally¡KI’m glad to find a lot of useful information right here within the post, we need develop more techniques in this regard, thank you for sharing. . . . . .

  16. A lot of thanks for all your efforts on this site. Betty enjoys doing research and it is obvious why. A number of us hear all concerning the compelling way you provide worthwhile tips via this blog and as well as inspire participation from others on that idea and my simple princess is now studying a whole lot. Take advantage of the remaining portion of the new year. You are doing a powerful job.

  17. What i do not realize is actually how you are not actually much more well-liked than you might be now. You’re so intelligent. You realize thus considerably relating to this subject, made me personally consider it from so many varied angles. Its like women and men aren’t fascinated unless it’s one thing to do with Lady gaga! Your own stuffs excellent. Always maintain it up!

  18. I do not even know how I ended up here, but I thought this post was great. I do not know who you are but definitely you are going to a famous blogger if you aren’t already 😉 Cheers!

  19. I in addition to my pals ended up digesting the good tactics located on your site and unexpectedly came up with an awful suspicion I never expressed respect to the blog owner for those tips. The people appeared to be very interested to read them and now have really been loving these things. Thank you for really being quite helpful and then for picking such tremendous things most people are really eager to be aware of. Our own sincere apologies for not expressing gratitude to you sooner.

  20. Today, with all the fast way of living that everyone is having, credit cards have a huge demand throughout the market. Persons from every area are using the credit card and people who are not using the card have prepared to apply for one in particular. Thanks for giving your ideas about credit cards.

  21. I am not sure where you’re getting your information, but great topic. I needs to spend some time learning more or understanding more. Thanks for great info I was looking for this info for my mission.

  22. Terrific paintings! This is the type of information that are meant to be shared across the internet. Shame on Google for now not positioning this publish higher! Come on over and consult with my website . Thanks =)

  23. I’ve been absent for some time, but now I remember why I used to love this web site. Thank you, I’ll try and check back more frequently. How frequently you update your web site?

  24. Good day! This post couldn’t be written any better! Reading this post reminds me of my old room mate! He always kept chatting about this. I will forward this article to him. Pretty sure he will have a good read. Many thanks for sharing!

  25. Hi would you mind stating which blog platform you’re working with? I’m planning to start my own blog in the near future but I’m having a hard time making a decision between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your design and style seems different then most blogs and I’m looking for something unique. P.S Apologies for getting off-topic but I had to ask!

  26. I have not checked in here for some time since I thought it was getting boring, but the last several posts are good quality so I guess I’ll add you back to my everyday bloglist. You deserve it my friend 🙂

  27. Does your website have a contact page? I’m having a tough time locating it but, I’d like to shoot you an email. I’ve got some suggestions for your blog you might be interested in hearing. Either way, great blog and I look forward to seeing it expand over time.

  28. Wow, marvelous blog layout! How long have you been blogging for? you made blogging look easy. The overall look of your website is great, let alone the content!

LEAVE A REPLY

Please enter your comment!
Please enter your name here