The five people were taken to the hospital and one person has died following the hit-and-run in San Francisco’s Central Waterfront neighborhood.
At least three of the other victims had life-threatening wounds, police said.
Police said they were searching for the driver.
“The driver of vehicle was in a physical altercation with five subjects and struck five subjects with his vehicle,” San Francisco police said in a statement. Police declined to immediately provide further details.
In video from NBC Bay Area, paramedics and police could be seen attending to a person lying on the sidewalk.
Paul Lim, who works at a business in the area, told the San Francisco Chronicle he saw the aftermath of the incident.
“I saw two lifeless people from across the street,” Lim told the newspaper. “Another one was being consoled by a friend screaming for help. And another one was moving very slowly.”
Reuters contributed to this article