Israel now has “full aerial superiority” over the Iranian capital, Tehran, its military said Monday, as the most devastating exchange between the two regional powers since the 1980s entered its fourth day.

Israel Defense Forces Spokesman Brig. Gen. Effie Defrin made the comment at a press briefing on Monday, saying they had “completed another wave of attacks in Tehran” which hit “more than 20 Iranian army and Quds force headquarters.”

“The wave of strikes last night opened with targeted strikes by air defense arrays designed to protect the centers of power of the Iranian army and a thorn force in the heart of Iran,” Defrin said.

The fighting began Friday when Israel launched Operation “Rising Lion,” a surprise attack targeting Iran’s nuclear facilities and military leadership. Israeli strikes hit the Natanz nuclear enrichment facility, along with sites in Fordow and Isfahan, while killing several top Iranian commanders including Islamic Revolutionary Guard Corps leader Hossein Salami and nuclear scientists Fereydoon Abbasi and Mohammad Mehdi Tehranchi.

The IDF also says it has destroyed 120 of Iran’s missile launchers.

“After hitting the defense systems, we attacked the headquarters with dozens of aircraft, simultaneously, including the headquarters of the Iranian nuclear project,” Defrin said. “These headquarters were deliberately placed inside buildings and high-rise buildings. The leaders of the regime thought that this was not how we would find them and they would remain immune. They’ve gone.”

Iran responded with waves of ballistic missiles targeting Israeli cities. The latest Iranian strikes hit Tel Aviv and the port city of Haifa early Monday, causing explosions and fires across both cities. In Bat Yam, near Tel Aviv, an Iranian missile destroyed an apartment building, killing seven people including five Ukrainian nationals. Israeli authorities report 18 killed and at least 380 injured from Iran’s missile strikes.

Both countries have closed their airspace, with Iraq and Jordan also shutting down flight operations. Iranians in major cities have been fleeing to safer areas, while Israeli civilians remain in bomb shelters across much of the country.