President Donald Trump has issued a fresh warning to Iran following Israel’s crippling strike against the regime’s nuclear infrastructure, demanding Tehran make a deal before facing “even more brutal” attacks.

“I gave Iran chance after chance to make a deal,” Trump wrote on Truth Social Friday morning. “There has already been great death and destruction, but there is still time to make this slaughter, with the next already planned attacks being even more brutal, come to an end and save what was once known as the Iranian Empire.”

Further warning Tehran must make a deal “before there is nothing left,” Trump’s ultimatum came hours after Israeli forces struck Iran’s main uranium enrichment facility at Natanz and other nuclear sites. Iran’s Atomic Energy Organization confirmed damage to Natanz but reported no casualties or radioactive contamination at the nuclear site.

Unlike his predecessor, Trump has taken a strong stand against Iran’s global jihad. In 2018, Trump first withdrew the United States from the 2015 Joint Comprehensive Plan of Action (JCPOA), calling it fundamentally flawed and reimposing crippling sanctions on Tehran. His administration argued the original deal “gave the Iranian regime too much in exchange for too little” and failed to address Iran’s missile program or regional proxy activities.

Seven years later, Trump reimposed his “maximum pressure” against Tehran by imposing heavy sanctions. However, this time around he has been pursuing a diplomatic path, with indirect negotiations with Iran through Omani mediation. U.S. and Iranian officials had been scheduled to hold a sixth round of talks in Oman on Sunday, but negotiations had stalled after Iran consistently rejected Trump’s demand for zero uranium enrichment, with Foreign Minister Abbas Araghchi stating bluntly: “No enrichment, no deal.”

Netanyahu had escalated pressure by warning that Iran possessed enough highly enriched uranium for nine atomic bombs and “is taking steps that it has never taken before, steps to weaponize this enriched uranium.”

During a televised address Friday, Iran’s President Masoud Pezeshkian declared Israel would “regret its foolish act.”

“Our response will be strong and calculated. Israel will face consequences that will make it regret its aggression,” he said.

Supreme Leader Ayatollah Ali Khamenei also vowed that Israel “must expect a severe punishment” for the attacks, declaring that Israel had created “a bitter and painful fate” for itself.

Several top Iranian commanders were reportedly killed in the strikes, including Major General Mohammad Bagheri, the armed forces chief of staff, and Revolutionary Guards chief Hossein Salami, along with six nuclear scientists.